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A, The 100-microelectrode array on top of a US penny. B, The microelectrode array in a scanning electron micrograph. C, The preoperative axial T1-weighted magnetic resonance image of the patient. The red square in the precentral gyrus shows the approximate location of the array. D, The patient sitting in a wheelchair and working with a technician on a brain-computer interface task. The gray arrow points to a percutaneous pedestal that contains the amplifier and other signal-acquisition hardware. Kennedy et al105 are continuing clinical trials of a system that uses intracortical microelectrodes encapsulated in glass cones, in which the neurites grow into the cones to provide stable and robust long-term recording. In 1998, this technology was implanted in a patient with locked-in syndrome after a brainstem stroke. At present, the striking achievements of BCI research and development remain confined almost entirely to the laboratory, and the bulk of work to date comprises data gathered from able-bodied humans or animals. Studies in the ultimate target population of people with severe disabilities have been largely confined to a few limited trials closely overseen by research personnel.
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